How to restore normal innate antitumor immunity in acute leukemia?

ABSTRACT

Restoration of immune functions is of importance in tumour eradication, more particularly regarding the residual disease. The challenge is probably to restore both innate and specific immune response, both required to overcome the various tumour escape mechanisms developed by leukemia cells. In the work of Lion et al., a simple method (electroporation of leukemic cell) may both restore NK and DC functions, leading to improved direct cytolysis by NK in addition to the development of a T-lymphocyte specific immune response.