Jun-B gene expression mediated by the surface immunoglobulin receptor of primary B lymphocytes.
Biochem Biophys Res Commun
; 175(1): 77-83, 1991 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-1900155
ABSTRACT
Stimulation of primary B lymphocytes induces the nuclear expression of TPA response element binding proteins that are recognized by anti-Jun antisera. To evaluate the profile of jun gene expression, RNA was extracted from B cells and probed for c-jun. Surprisingly, c-jun mRNA was not detected either before or after stimulation with anti-Ig. Instead, stimulation through the sIg antigen receptor, or with phorbol ester containing regimens, rapidly induced expression of the related jun-B. This demonstrates a lack of coordinate regulation for jun-B and c-jun expression in these primary B cells. The role of Jun-containing TRE binding proteins in promoting B cell cycle progression remains uncertain inasmuch as Jun-B has been associated with transcriptional inhibition of the TPA response element, rather than activation as produced by c-Jun.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proto-Oncogenes
/
Linfocitos B
/
Receptores Inmunológicos
/
Proteínas de Unión al ADN
Límite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
1991
Tipo del documento:
Article