Polypropylene meshes to prevent abdominal herniation. Can stable coatings prevent adhesions in the long term?
Ann Biomed Eng
; 37(2): 410-8, 2009 Feb.
Article
en En
| MEDLINE
| ID: mdl-19034665
ABSTRACT
Abdominal surgery is associated with a significant risk for incisional herniation. Hernia repair is routinely performed by implantation of synthetic meshes. Such meshes may cause serious adhesions between the implanted material and organs leading to intestinal obstruction or enterocutaneous fistulas. This study compares three knitted meshes for their capacity to prevent adhesion formation in an in vivo study. The meshes evaluated are polypropylene (Prolene), polypropylene coated with oxygenated regenerated cellulose-in principle-a biodegradable biomaterial (Proceed, and Prolene coated with a nondegradable copolymer of the hydrophilic building block N-vinyl pyrrolidone (NVP) and the hydrophobic building block n-butylmethacrylate (BMA). The meshes were implanted in the abdomen of rats (follow-up 7 or 30 days). After 7 days, the formation of adhesions decreased in the order Prolene > NVP/BMA-coated Prolene > Proceed; after 30 days, this order changed into Proceed > Prolene > NVP/BMA-coated Prolene. Both at 7 and at 30 days, Proceed was the only mesh surrounded by macrophage cells that contained foreign materials, presumably degradation products of the (biodegradable) surface coating. The data indicate that long-term protection of implanted meshes against excessive adhesions may be achieved through stable biocompatible hydrogel surface coatings.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polipropilenos
/
Mallas Quirúrgicas
/
Hernia Abdominal
Límite:
Animals
Idioma:
En
Revista:
Ann Biomed Eng
Año:
2009
Tipo del documento:
Article
País de afiliación:
Países Bajos