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Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes.
Baschal, Erin E; Aly, Theresa A; Jasinski, Jean M; Steck, Andrea K; Noble, Janelle A; Erlich, Henry A; Eisenbarth, George S.
Afiliación
  • Baschal EE; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Building M20, Aurora, CO 80045-6511, USA.
Clin Immunol ; 132(2): 203-14, 2009 Aug.
Article en En | MEDLINE | ID: mdl-19427271
The availability of both HLA data and genotypes for thousands of SNPs across the major histocompatibility complex (MHC) in 1240 complete families of the Type 1 Diabetes Genetics Consortium allowed us to analyze the occurrence and extent of megabase contiguous identity for founder chromosomes from unrelated individuals. We identified 82 HLA-defined haplotype groups, and within these groups, megabase regions of SNP identity were readily apparent. The conserved chromosomes within the 82 haplotype groups comprise approximately one third of the founder chromosomes. It is currently unknown whether such frequent conservation for groups of unrelated individuals is specific to the MHC, or if initial binning by highly polymorphic HLA alleles facilitated detection of a more general phenomenon within the MHC. Such common identity, specifically across the MHC, impacts type 1 diabetes susceptibility and may impact transplantation between unrelated individuals.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Haplotipos / Polimorfismo de Nucleótido Simple / Complejo Mayor de Histocompatibilidad Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Haplotipos / Polimorfismo de Nucleótido Simple / Complejo Mayor de Histocompatibilidad Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Estados Unidos