Your browser doesn't support javascript.
loading
Evidence for anti-tumour effect of allogeneic haematopoietic SCT in cases without sustained donor engraftment.
Daguindau, E; Lioure, B; Buzyn, A; Robin, M; Faucher, C; Kuentz, M; Tiberghien, P; Deconinck, E.
Afiliación
  • Daguindau E; Service d'Hématologie, Centre Hospitalier Universitaire Jean Minjoz, Besançon France. edeconinck@chu-besancon.fr
Bone Marrow Transplant ; 45(1): 177-80, 2010 Jan.
Article en En | MEDLINE | ID: mdl-19430502
Remissions of haematological malignancies have been reported after allo-SCT, despite donor cell rejection, suggesting that sustained allogeneic engraftment is not mandatory to obtain a lasting anti-tumour effect. To evaluate the potential benefit from transient post-allo-SCT alloreactivity, we took advantage of the Société Française de Greffe de Moëlle et Thérapie Cellulaire (SFGM-TC) registry to colligate 14 patients with an efficient and long-lasting allogeneic (GVL) effect after allo-SCT for haematological malignancies, despite transient or absent engraftment. None received a second allogeneic graft after autologous recovery. The median duration of remission after autologous reconstitution was 118 (12-252) months. Although we cannot exclude the possibility that some patients were cured before allo-SCT, this retrospective analysis does strongly suggest that an efficient GVL effect can be observed without sustained donor engraftment, and that the transient presence of donor T cells might be sufficient to induce a powerful GVL effect.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inmunoterapia Adoptiva / Trasplante de Células Madre Hematopoyéticas / Neoplasias Hematológicas / Efecto Injerto vs Leucemia Límite: Adult / Child, preschool / Humans / Middle aged Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2010 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inmunoterapia Adoptiva / Trasplante de Células Madre Hematopoyéticas / Neoplasias Hematológicas / Efecto Injerto vs Leucemia Límite: Adult / Child, preschool / Humans / Middle aged Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2010 Tipo del documento: Article