Expression of p53 and p16 in actinic keratosis, bowenoid actinic keratosis and Bowen's disease.
J Eur Acad Dermatol Venereol
; 24(2): 228-30, 2010 Feb.
Article
en En
| MEDLINE
| ID: mdl-19515076
ABSTRACT
INTRODUCTION:
Bowen's disease (BD) and bowenoid actinic keratosis (bAK) have traditionally been differentiated according to the presence or absence of dysplasia in the follicular epithelium. p16 has been suggested to be a useful tool to make the differential diagnosis between BD and AK and as a marker of bad prognosis. MATERIALS Five biopsies of BD, five of AK and five of bAK where stained for p53 and p16.RESULTS:
All lesions showed positive immunostaining of p53, affecting to the lower two thirds of the epidermis in BD and bAK, and only the basal layer in non-bAK. All the BD and bAK cases were positive for p16, showing a similar immunostaining pattern, whereas no staining was observed in non-bAK. DISCUSSION ANDCONCLUSION:
These findings suggest a common pathogenic mechanism for BD and bAK. bAK might have worse prognosis than AK. p16 might not be useful as a tool for differential diagnosis between AK and BD because bAK and BD show an extremely similar immunohistochemical pattern.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Bowen
/
Proteína p53 Supresora de Tumor
/
Genes p16
/
Queratosis Actínica
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Eur Acad Dermatol Venereol
Asunto de la revista:
DERMATOLOGIA
/
DOENCAS SEXUALMENTE TRANSMISSIVEIS
Año:
2010
Tipo del documento:
Article
País de afiliación:
España