Cyclic adenylic acid-dependent and -independent production of chloramphenicol acetyltransferase in Escherichia coli carrying R plasmids.
Antimicrob Agents Chemother
; 11(6): 952-5, 1977 Jun.
Article
en En
| MEDLINE
| ID: mdl-195517
ABSTRACT
A plasmid-specified, inducible, but cyclic adenylic acid (cAMP)-independent resistance to chloramphenicol (CM) is reported. The resistance level to CM was increased two- to fourfold by treatment with a small amount of CM for a short period in Escherichia coli strains carrying the R plasmid pJY1, which was obtained from a clinical isolate of Vibrio cholerae. Though cAMP was required for production of CM acetyltransferase (CATase) in cAMP-deficient mutants of E. coli carrying the R100 plasmid, the same species harboring pJY1 did not require cAMP for production of the enzyme. The possibility of a mechanism other than CATase activity for the CM resistance conferred by R plasmids is discussed.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Acetiltransferasas
/
Farmacorresistencia Microbiana
/
Factores R
/
Cloranfenicol
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Escherichia coli
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
1977
Tipo del documento:
Article