Autobiographical memory in progressive supranuclear palsy.

ABSTRACT

BACKGROUND: We aimed to investigate recall of autobiographical memories across lifetime periods in patients with progressive supranuclear palsy (PSP). METHOD: Patients with PSP (n = 10) were given a test of autobiographical and personal semantic information and the Addenbrooke's Cognitive Examination (ACE). The result was compared to 30 matched neurologically intact participants. RESULT: A mild autobiographical memory impairment was observed in PSP without a temporal gradient for the recall of autobiographical or personal semantic information. Performance correlated with verbal fluency in ACE. CONCLUSION: Patients with PSP show mild deficits in autobiographical memory, which is likely to reflect a frontal retrieval deficit.