Levels of dendritic cell populations and regulatory T cells vary significantly between two commonly used mouse strains.
Scand J Immunol
; 70(6): 541-6, 2009 Dec.
Article
en En
| MEDLINE
| ID: mdl-19906196
ABSTRACT
Dendritic cells (DC) are a heterogeneous group of professional antigen-presenting cells (APC) involved in both initiating immune responses and maintaining tolerance. Roughly, DC can be divided into plasmacytoid DC (pDC) and conventional DC (cDC). By controlling regulatory T cells (Treg), DC can influence the outcome of both immunity and autoimmunity. Since the use of mice as in vivo models became a practical tool for researchers studying pathological events in all kind of human diseases, we decided to compare levels of cDC, pDC and Treg in both spleen and blood between two inbred mouse strains. Here we show that two commonly used mouse strains, BALB/c and C57BL/10J mice, have significantly different levels of distinct CD11c(+)/CD4(-)/CD8a(+), CD11c(+)/CD4(+)/CD8a(-) and CD11c(+)/CD4(-)/CD8a(-) cDC populations, pDC and Treg. Therefore, we emphasize the importance of considering the proper model when comparing data sets from different mouse strains.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Células Dendríticas
/
Linfocitos T Reguladores
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Scand J Immunol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Noruega