Regulation of lymphatic-blood vessel separation by endothelial Rac1.
Development
; 136(23): 4043-53, 2009 Dec.
Article
en En
| MEDLINE
| ID: mdl-19906871
ABSTRACT
Sprouting angiogenesis and lymphatic-blood vessel segregation both involve the migration of endothelial cells, but the precise migratory molecules that govern the decision of blood vascular endothelial cells to segregate into lymphatic vasculature are unknown. Here, we deleted endothelial Rac1 in mice (Tie1-Cre(+);Rac1(fl/fl)) and revealed, unexpectedly, that whereas blood vessel morphology appeared normal, lymphatic-blood vessel separation was impaired, with corresponding edema, haemorrhage and embryonic lethality. Importantly, normal levels of Rac1 were essential for directed endothelial cell migratory responses to lymphatic-inductive signals. Our studies identify Rac1 as a crucial part of the migratory machinery required for endothelial cells to separate and form lymphatic vasculature.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vasos Sanguíneos
/
Regulación del Desarrollo de la Expresión Génica
/
Proteína de Unión al GTP rac1
/
Células Endoteliales
/
Vasos Linfáticos
Límite:
Animals
Idioma:
En
Revista:
Development
Asunto de la revista:
BIOLOGIA
/
EMBRIOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Reino Unido