Role of IL-13 in a model of Strongyloides venezuelensis infection in rats.
Microbes Infect
; 12(5): 409-14, 2010 May.
Article
en En
| MEDLINE
| ID: mdl-20116445
ABSTRACT
IL-13 is a cytokine known to play a role in several pulmonary diseases, including asthma and fibrosis. The role of IL-13 in the context of pulmonary changes induced by helminth infection is unclear. Rats experimentally infected with Strongyloides venezuelensis and treated with anti-IL-13 neutralizing antibody were used to evaluate the role of IL-13 on functional and inflammatory changes of host lungs, and on parasite control. S. venezuelensis-induced airway hyperreactivity was IL-13-independent, but IL-13 played an essential role in driving airway mucus production and eosinophil infiltration. IL-13 was important for the control of egg production but not establishment in the intestine.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Strongyloides
/
Estrongiloidiasis
/
Interleucina-13
Límite:
Animals
Idioma:
En
Revista:
Microbes Infect
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
MICROBIOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Brasil