Effect of abrupt discontinuation versus gradual dose reduction of postmenopausal hormone therapy on hot flushes.
Climacteric
; 13(4): 362-7, 2010 Aug.
Article
en En
| MEDLINE
| ID: mdl-20151792
ABSTRACT
OBJECTIVE:
To compare the effects of the abrupt discontinuation of postmenopausal hormone therapy (HT) and reduction of the daily dosage of the hormone on climacteric symptoms.METHODS:
The study included Brazilian postmenopausal women who were using estrogen-progestogen hormone therapy in full doses previously prescribed for vasomotor symptoms. The patients were randomized to receive one of three treatments placebo for 6 months; estradiol (E2) 1 mg/day + norethisterone acetate (NETA) 0.5 mg/day for 2 months, followed by placebo for 4 months; or E2 1 mg/day + NETA 0.5 mg/day for 4 months, followed by placebo for 2 months. The climacteric symptoms were assessed by the Blatt-Kupperman Menopausal Index at baseline and at 2, 4 and 6 months. Statistical evaluation was performed using the chi(2) or Fisher's test for categorical data, the Kruskal-Wallis test for numerical data, and ANOVA for time and group relationship with the Blatt-Kupperman Menopausal Index.RESULTS:
We randomized 60 women (20 in each group), and 54 completed the study. It was observed that both the full Blatt-Kupperman Menopausal Index and the hot flush score did not change significantly in the HT group during low-dose therapy compared with baseline; however, the evaluation performed at 2 months after low-dose-HT cessation showed that the full Blatt-Kupperman Menopausal Index and the hot flush score were similar to those of the group who stopped HT abruptly and significantly higher than at baseline (hot flush scores p < 0.001 for all three groups at months 2, 4 and 6, respectively, vs. baseline).CONCLUSION:
Discontinuation of HT by reducing the daily dose of estrogen for a period of 2 or 4 months did not differ in its effect from that of abrupt cessation with regard to vasomotor symptoms.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Terapia de Reemplazo de Estrógeno
/
Sofocos
/
Estradiol
Tipo de estudio:
Clinical_trials
Límite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Climacteric
Asunto de la revista:
GINECOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Brasil