Mutant TNF-alpha, mTNF-K90R, is a novel candidate adjuvant for a mucosal vaccine against HIV.
Pharmazie
; 65(4): 254-6, 2010 Apr.
Article
en En
| MEDLINE
| ID: mdl-20432620
ABSTRACT
The development of a safe and effective mucosal vaccine adjuvant is a crucial step for the development of vaccines against human immunodeficiency virus type-1 (HIV). We have previously reported that a mutant tumor necrosis factor-alpha (TNF-alpha), mTNF-K90R, possessed strong mucosal vaccine adjuvant activities in mice. Here, we evaluated the potential of mTNF-K90R as a mucosal vaccine adjuvant for the induction of systemic and mucosal immune responses against HIV. Nasal immunization of BALB/c mice with 5 microg of an HIV gp120 env protein immunogen together with mTNF-K90R induced higher serum anti-HIV gp120 protein immunoglobulin G (IgG) responses than gp120 alone. Furthermore, mTNF-K90R induced anti-gp120 IgA responses in nasal as well as vaginal washes from immunized mice, although these were not administration sites. Again, responses with mTNF-K90R were higher than with gp120 alone. These results indicate that mTNF-K90R may be applicable as amucosal adjuvant for HIV vaccination to induce both systemic and mucosal immune responses.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Adyuvantes Inmunológicos
/
Factor de Necrosis Tumoral alfa
/
Vacunas contra el SIDA
/
Inmunidad Mucosa
Límite:
Animals
Idioma:
En
Revista:
Pharmazie
Asunto de la revista:
FARMACIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Japón