A multistate model for events defined by prolonged observation.
Biostatistics
; 12(1): 102-11, 2011 Jan.
Article
en En
| MEDLINE
| ID: mdl-20581216
ABSTRACT
Time-to-event and similar analyses can be problematic if the event of interest is operationally defined by some condition being true for a prolonged period of time. A particular example of this, remission in psoriatic arthritis, is considered in detail for illustration. A 3-state model is proposed for characterizing the transition rates into and out of remission. Remission is linked to an initial and subsequent state for the purpose of introducing the condition that remission must be of some duration to be clinically meaningful. The model is compared with alternative approaches that have been used in such situations. These involve 2-state models where the duration of remission is allowed for through different definitions for the time of entry into remission. Both definitions are linked to prolonged observation of a particular clinical state.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Remisión Espontánea
/
Artritis Psoriásica
/
Modelos Estadísticos
/
Modelos Biológicos
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Biostatistics
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido