Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line.
Bioorg Med Chem Lett
; 20(19): 5722-5, 2010 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-20797858
ABSTRACT
The synthesis of a novel series of aminoquinazoline derivatives 1a-r and their antiproliferative activities against A375 human melanoma cell line were described. Among them, six compounds showed superior antiproliferative activities to Sorafenib as a reference compound. In particular, the representative compound 1q bearing chromen-4-one moiety exhibited excellent antiproliferative activity (IC(50)=0.006 µM) and good selectivity over HS27 fibroblast cell line.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Quinazolinas
/
Cromonas
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2010
Tipo del documento:
Article