The Notch signaling pathway: molecular basis of cell context dependency.
Eur J Cell Biol
; 90(6-7): 572-81, 2011.
Article
en En
| MEDLINE
| ID: mdl-21126799
ABSTRACT
Notch receptor signaling controls cell-fate specification, self-renewal, differentiation, proliferation and apoptosis throughout development and regeneration in all animal species studied to date. Its dysfunction causes several developmental defects and diseases in the adult. A key feature of Notch signaling is its remarkable cell-context dependency. In this review, we summarize the influences of the cellular context that regulate Notch activity and propose a model how the interplay between the cell-intrinsically established chromatin state and the cell-extrinsic signals that modify chromatin may select for Notch target accessibility and activation in different cellular contexts.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores Notch
Límite:
Humans
Idioma:
En
Revista:
Eur J Cell Biol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Alemania