Lowland origin women raised at high altitude are not protected against lower uteroplacental O2 delivery during pregnancy or reduced birth weight.
Am J Hum Biol
; 23(4): 509-16, 2011.
Article
en En
| MEDLINE
| ID: mdl-21538651
ABSTRACT
OBJECTIVE:
Maternal physiologic responses to pregnancy promoting fetal oxygen and nutrient delivery are important determinants of reproductive success. Incomplete physiologic compensation for reduced oxygen availability at high altitude (≥2,500 m) compromises fetal growth. Populations of highland (e.g., Andeans, Tibetans) compared with lowland origin groups (e.g., Europeans, Han Chinese) are protected from this altitude-associated decrease in birth weight; here we sought to determine whether maternal development at high altitude-rather than highland ancestry-contributed to the protection of birth weight and uterine artery (UA) blood flow during pregnancy.METHODS:
In women of lowland ancestry who were either raised at high altitude in La Paz, Bolivia (3,600-4,100 m) ("lifelong," n = 18) or who had migrated there as adults ("newcomers," n = 40) we compared maternal O(2) transport during pregnancy and their infant's birth weight.RESULTS:
Pregnancy raised maternal ventilation and arterial O(2) saturation equally, with the result that arterial O(2) content was similarly maintained at nonpregnant levels despite a fall in hemoglobin. UA blood flow and uteroplacental O(2) delivery were lower in lifelong than newcomer residents (main effect). Birth weight was similar in lifelong residents versus newcomers (2,948 ± 93 vs. 3,090 ± 70 gm), with both having values below those of a subset of eight high-altitude residents who descended to deliver at low altitude (3,418 ± 133 gm, P < 0.05).CONCLUSION:
Lifelong compared with newcomer high-altitude residents have lower uteroplacental O(2) delivery and similar infant birth weights, suggesting that developmental factors are likely not responsible for the protective effect of highland ancestry.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oxígeno
/
Recién Nacido de Bajo Peso
/
Resultado del Embarazo
/
Adaptación Fisiológica
/
Salud de la Mujer
/
Altitud
/
Arteria Uterina
Límite:
Adult
/
Child
/
Female
/
Humans
/
Newborn
/
Pregnancy
País/Región como asunto:
America do sul
/
Bolivia
Idioma:
En
Revista:
Am J Hum Biol
Asunto de la revista:
BIOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos