[Perspectives and current state in limbal stem cell transplantation]. / Perspektiven und aktueller Stand der Limbusstammzelltransplantation.
Ophthalmologe
; 108(9): 840-5, 2011 Sep.
Article
en De
| MEDLINE
| ID: mdl-21909872
ABSTRACT
The transplantation of limbal stem cells is one of the most challenging surgical approaches in ocular surface reconstruction. Partial and unilateral limbal stem cell insufficiency (LSCI) can be treated by fractionated abrasion or autologous limbal stem cell transplantation from the fellow eye. In cases of advanced bilateral and partial LSCI, ex vivo expansion of limbal stem cells on amniotic membranes or fibrin can be performed but all patients with complete bilateral LSCI must rely on allogenic limbal stem cell transplantation with high immunological risks. Attempts to combine allogenic limbal stem cell transplantation with mitomycin C and amniotic membrane transplantation are promising. In the laboratory, attempts to transdifferentiate bone marrow stem cells into corneal epithelial cells have been without success. Nonetheless, transdifferentiation of hair follicle stem cells into corneal epithelial cells looks promising. In parallel, research on the limbal stem cell niche is ongoing to elucidate the natural environment of limbal stem cells in order to improve ex vivo culture.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Limbo de la Córnea
/
Enfermedades de la Córnea
/
Trasplante de Células Madre
Límite:
Humans
Idioma:
De
Revista:
Ophthalmologe
Asunto de la revista:
OFTALMOLOGIA
Año:
2011
Tipo del documento:
Article