Size-dependent immune-modulating effect of amorphous nanosilica particles.
Pharmazie
; 66(9): 727-8, 2011 Sep.
Article
en En
| MEDLINE
| ID: mdl-22026132
ABSTRACT
The immune-modulating effect following intradermal injection of various-sized amorphous silica particles was analyzed in terms of induction of ovalbumin-specific CD8+ T cells in vivo. IFN-gamma ELISPOT assays revealed that only nanosilica particles with a diameter of less than 100 nm significantly enhanced CD8+ T cell responses against ovalbumin. These results indicate that the size of nanomaterials is a critical determinant in terms of their safe use.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dióxido de Silicio
/
Nanopartículas
/
Factores Inmunológicos
Límite:
Animals
Idioma:
En
Revista:
Pharmazie
Asunto de la revista:
FARMACIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón