Histomorphometric analysis of the effects of creatine on rat myometrium.
Gynecol Endocrinol
; 28(8): 587-9, 2012 Aug.
Article
en En
| MEDLINE
| ID: mdl-22309498
ABSTRACT
OBJECTIVE:
To analyze the myometrial thickness of rats subjected to creatine (Cr) ingestion. STUDYDESIGN:
A total of 14 rats was equally divided into the control group (ConGr) receiving 1 ml potable water and the creatine group (CrGr) subjected to the ingestion of 1.6 g/kg Cr diluted in 1 ml potable water. At the end of 8 weeks, the animals were anesthetized (xylazine and ketamine) and sacrificed, the uteri and ovaries stained with hematoxylin and eosin, the thickness of both the myometrium and the epithelium measured and the follicles counted.RESULTS:
Analysis revealed a significant increase in thickness of the myometrium in the CrGr (272.26 ± 66.71µm) contrasted with that from the ConGr (160.76 ± 35.65µm), CrGr > ConGr (p < 0001).CONCLUSION:
Our data suggest that Cr changed myometrial morphology in rats by enhancing myometrial thickness, but its action mechanism in the smooth muscle is still unclear.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Suplementos Dietéticos
/
Creatina
/
Sustancias para Mejorar el Rendimiento
/
Miometrio
Límite:
Animals
Idioma:
En
Revista:
Gynecol Endocrinol
Asunto de la revista:
ENDOCRINOLOGIA
/
GINECOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Brasil