PD-L1 co-stimulation, ligand-induced TCR down-modulation and anti-tumor immunotherapy.
Oncoimmunology
; 1(1): 86-88, 2012 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-22318430
ABSTRACT
PD-1 engagement on the surface of effector T cells strongly suppresses their cytotoxic function, which constitutes a major obstacle for T cell-mediated anti-tumor activities. Surprisingly, PD-1 is strongly upregulated in T cells, engaging its ligand PD-L1 during antigen presentation. However, our recent published data may provide an explanation for this apparent contradiction.
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Colección:
01-internacional
Banco de datos:
MEDLINE
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En
Revista:
Oncoimmunology
Año:
2012
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Article