Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity.
Arch Physiol Biochem
; 118(2): 58-68, 2012 May.
Article
en En
| MEDLINE
| ID: mdl-22364223
ABSTRACT
CONTEXT Adipose tissue is one of the first organs to develop insulin resistance even with moderate BMI. However, the contribution of developing hyperglycaemia and concomitant methylglyoxal increment to tissue dysfunction during type 2 diabetes progression was not addressed before. METHODS:
Young and aged Wistar and Goto-Kakizaki rats (non-obese model of type 2 diabetes) and a group of MG-treated W rats were used to investigate the chronic effects of hyperglycaemia and ageing and specifically MG-induced mechanisms.RESULTS:
Diabetic and aged rats showed decreased adipose tissue irrigation and interstitial hypoxia. Hyperglycaemia of diabetic rats leaded to fibrosis and accumulation of PAS-positive components, exacerbated in aged animals, which also showed decreased hipoadiponectinemia, increased MCP-1 expression and macrophage infiltration to glycated fibrotic regions. MG leaded to increased free fatty acids, hipoadiponectinemia, decreased irrigation, hypoxia and macrophage recruitment for glycated fibrotic regions.CONCLUSIONS:
MG contributes to dysfunction of adipose tissue during type 2 diabetes progression.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piruvaldehído
/
Tejido Adiposo
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Arch Physiol Biochem
Asunto de la revista:
BIOQUIMICA
/
FISIOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Portugal