Protective effect of Heliotropium eichwaldi against cisplatin-induced nephrotoxicity in mice.
Zhong Xi Yi Jie He Xue Bao
; 10(5): 555-60, 2012 May.
Article
en En
| MEDLINE
| ID: mdl-22587978
ABSTRACT
OBJECTIVE:
The aim of the present study was to evaluate the nephroprotective effect of methanolic extract of Heliotropium eichwaldii (MHE) in mice with cisplatin-induced acute renal damage.METHODS:
Nephrotoxicity was induced by a single intraperitoneal injection of cisplatin (16mg/kg). Swiss albino mice were injected with vehicle, cisplatin, cisplatin plus MHE 200 mg/kg and cisplatin plus MHE 400mg/kg, respectively. MHE was administered for 7 d at a dose of 200 and 400 mg/kg per day orally starting 4 d before cisplatin injection. Animals were sacrificed 3d after treatment and blood as well as kidney tissue was isolated and analyzed. The various parameters such as blood urea nitrogen (BUN), serum creatinine (CRE), malondialdehyde (MDA), and catalase (CAT) and superoxide dismutase (SOD) activities were analyzed.RESULTS:
MHE treatment significantly reduced BUN and serum CRE levels elevated by cisplatin administration (P<0.05). Also, it significantly attenuated cisplatin-induced increase in MDA level and improved the decreased CAT and SOD activities in renal cortical homogenates (P<0.05). Additionally, histopathological examination and scoring showed that MHE markedly ameliorated cisplatin-induced renal tubular necrosis.CONCLUSION:
MHE can be considered a potential candidate for protection of nephrotoxicity induced by cisplatin.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Heliotropium
/
Lesión Renal Aguda
/
Riñón
Límite:
Animals
Idioma:
En
Revista:
Zhong Xi Yi Jie He Xue Bao
Asunto de la revista:
MEDICINA
/
TERAPIAS COMPLEMENTARES
Año:
2012
Tipo del documento:
Article
País de afiliación:
India