Panel of prototypical recombinant infectious molecular clones resistant to nevirapine, efavirenz, etravirine, and rilpivirine.
Antimicrob Agents Chemother
; 56(8): 4522-4, 2012 Aug.
Article
en En
| MEDLINE
| ID: mdl-22664973
ABSTRACT
We created a panel of 10 representative multi-nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant recombinant infectious molecular HIV-1 clones to assist researchers studying NNRTI resistance or developing novel NNRTIs. The cloned viruses contain most of the major NNRTI resistance mutations and most of the significantly associated mutation pairs that we identified in two network analyses. Each virus in the panel has intermediate- or high-level resistance to all or three of the four most commonly used NNRTIs.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
VIH-1
/
Inhibidores de la Transcriptasa Inversa
/
Fármacos Anti-VIH
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Farmacorresistencia Viral
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Farmacorresistencia Viral Múltiple
/
Transcriptasa Inversa del VIH
Límite:
Humans
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos