Hedgehog controls hepatic stellate cell fate by regulating metabolism.

Chen, Yuping; Choi, Steve S; Michelotti, Gregory A; Chan, Isaac S; Swiderska-Syn, Marzena; Karaca, Gamze F; Xie, Guanhua; Moylan, Cynthia A; Garibaldi, Francesca; Premont, Richard; Suliman, Hagir B; Piantadosi, Claude A; Diehl, Anna Mae

Chen, Yuping; Choi, Steve S; Michelotti, Gregory A; Chan, Isaac S; Swiderska-Syn, Marzena; Karaca, Gamze F; Xie, Guanhua; Moylan, Cynthia A; Garibaldi, Francesca; Premont, Richard; Suliman, Hagir B; Piantadosi, Claude A; Diehl, Anna Mae.

Afiliación

Chen Y; Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Choi SS; Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; Section of Gastroenterology, Department of Medicine, Durham Veterans Affairs Medical Center, Durham, North Carolina.
Michelotti GA; Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Chan IS; Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Swiderska-Syn M; Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Karaca GF; Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Xie G; Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Moylan CA; Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; Section of Gastroenterology, Department of Medicine, Durham Veterans Affairs Medical Center, Durham, North Carolina.
Garibaldi F; Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Premont R; Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Suliman HB; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Piantadosi CA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina; Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina; Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Diehl AM; Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina. Electronic address: diehl004@mc.duke.edu.

Gastroenterology ; 143(5): 1319-1329.e11, 2012 Nov.

Article en En | MEDLINE | ID: mdl-22885334

Asunto(s)

Transdiferenciación Celular/genética; Regulación de la Expresión Génica; Proteínas Hedgehog/genética; Proteínas Hedgehog/metabolismo; Células Estrelladas Hepáticas/metabolismo; Miofibroblastos/metabolismo; Transducción de Señal/genética; Actinas/genética; Actinas/metabolismo; Animales; Conductos Biliares; Tetracloruro de Carbono; Células Cultivadas; Perfilación de la Expresión Génica; Glucólisis/genética; Células Estrelladas Hepáticas/citología; Células Estrelladas Hepáticas/enzimología; Humanos; Subunidad alfa del Factor 1 Inducible por Hipoxia; Ácido Láctico/metabolismo; Ligadura; Cirrosis Hepática/inducido químicamente; Cirrosis Hepática/genética; Cirrosis Hepática/metabolismo; Masculino; Ratones; Ratones Endogámicos C57BL; Mitocondrias; Miofibroblastos/enzimología; Piruvato Quinasa/genética; Piruvato Quinasa/metabolismo; ARN Mensajero/metabolismo; Ratas; Factores de Tiempo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Regulación de la Expresión Génica / Proteínas Hedgehog / Transdiferenciación Celular / Células Estrelladas Hepáticas / Miofibroblastos Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Gastroenterology Año: 2012 Tipo del documento: Article

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