HLA-B*58:01 allele is associated with augmented risk for both mild and severe cutaneous adverse reactions induced by allopurinol in Han Chinese.
Pharmacogenomics
; 13(10): 1193-201, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-22909208
ABSTRACT
AIM:
Allopurinol is widely used as an effective urate-lowering drug and is one of the most frequent causes of cutaneous adverse drug reactions (cADRs). Recently, a strong association of HLA-B*5801 with allopurinol-induced severe cADRs was identified. This study investigated the predisposition to different types of allopurinol-cADRs conferred by HLA-B*5801 in a Han population from mainland China. PATIENTS &METHODS:
HLA-B genotyping was performed on 38 Chinese patients with different types of allopurinol-cADRs from 2008 to 2011.RESULTS:
All the allopurinol-cADR patients carried HLA-B*5801, in contrast with only 11.11% (7/63) in the allopurinol-tolerant patients (odds ratio [OR] = 580.07; p < 0.0001) and 13.99% (80/572) in a Han Chinese population from the human MHC database (dbMHC; OR 471.09; p < 0.0001) carried the genotype. Each type of allopurinol cADRs revealed a statistically significant association with HLA-B*5801. In particular, the risk of allopurinol-induced maculopapular eruption was significantly higher in patients with HLA-B*5801 (OR 339.00; p < 0.0001).CONCLUSION:
The strong association of both the mild and severe types of allopurinol cADRs with the HLA-B*5801 allele were observed. The results indicated that the prospective use of a genetic test of HLA-B*5801 might reduce the prevalence of allopurinol-induced cADRs. Original submitted 7 March 2012; Revision submitted 21 May 2012.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antígenos HLA-B
/
Alopurinol
/
Síndrome de Stevens-Johnson
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
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Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Pharmacogenomics
Asunto de la revista:
FARMACOLOGIA
/
GENETICA MEDICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
China