Amorphous nanosilica particles induce ROS generation in Langerhans cells.
Pharmazie
; 67(8): 740-1, 2012 Aug.
Article
en En
| MEDLINE
| ID: mdl-22957442
ABSTRACT
Generation of total intracellular reactive oxygen species (ROS) was measured in XS52 cells, a Langerhans cell-like line, treated with different sized amorphous silica particles. The results suggested that exposure to amorphous nanosilica particles (nSPs) with a particle size of 70 nm induced a higher level of ROS generation than did exposure to micron-sized amorphous silica particles. This finding means that it is essential to examine the biological effects of ROS generated after exposure to nSPs, which will provide useful information for hazard identification as well as the design of safer nanomaterials.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células de Langerhans
/
Especies Reactivas de Oxígeno
/
Dióxido de Silicio
/
Nanopartículas
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Pharmazie
Asunto de la revista:
FARMACIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Japón