Dermal absorption of amorphous nanosilica particles after topical exposure for three days.
Pharmazie
; 67(8): 742-3, 2012 Aug.
Article
en En
| MEDLINE
| ID: mdl-22957443
ABSTRACT
The skin penetration and cellular localization of well-dispersed amorphous nanosilica particles (nSPs) with a diameter of 70 nm was analyzed in mice. Our results suggest that after topical exposure for three days the particles penetrate the skin barrier and are transported to the lymph nodes. These findings underscore the need to examine biological effects following dermal exposure to nSPs for the development of safer use of nSPs.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Absorción Cutánea
/
Dióxido de Silicio
/
Nanopartículas
Límite:
Animals
Idioma:
En
Revista:
Pharmazie
Asunto de la revista:
FARMACIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Japón