Insulin-regulated aminopeptidase and its compartment in dendritic cells.
Mol Immunol
; 55(2): 153-5, 2013 Sep.
Article
en En
| MEDLINE
| ID: mdl-23123036
ABSTRACT
Peptide epitopes presented by MHC class I molecules are produced through sequential proteolysis, frequently terminating with an aminoterminal trimming step. While the trimming enzymes processing endogenous MHC class I ligands in the endoplasmic reticulum have by now been characterized extensively, we have only recently identified an endosomal enzyme, insulin-regulated aminopeptidase (IRAP) that can trim cross-presented peptides derived from proteins internalized by dendritic cells. Here we summarize the essential features of IRAP as a trimming enzyme, propose an updated model of cellular cross-presentation pathways, and discuss potential additional functions of IRAP and its compartment in dendritic cell biology.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cistinil Aminopeptidasa
/
Células Dendríticas
/
Reactividad Cruzada
Límite:
Humans
Idioma:
En
Revista:
Mol Immunol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Francia