GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice.
Blood
; 121(10): 1749-59, 2013 Mar 07.
Article
en En
| MEDLINE
| ID: mdl-23287858
ABSTRACT
Transcription factors orchestrate T-lineage differentiation in the thymus. One critical checkpoint involves Notch1 signaling that instructs T-cell commitment at the expense of the B-lineage program. While GATA-3 is required for T-cell specification, its mechanism of action is poorly understood. We show that GATA-3 works in concert with Notch1 to commit thymic progenitors to the T-cell lineage via 2 distinct pathways. First, GATA-3 orchestrates a transcriptional "repertoire" that is required for thymocyte maturation up to and beyond the pro-T-cell stage. Second, GATA-3 critically suppresses a latent B-cell potential in proT cells. As such, GATA-3 is essential to sealing in Notch-induced T-cell fate in early thymocyte precursors by promoting T-cell identity through the repression of alternative developmental options.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Timo
/
Linfocitos B
/
Linfocitos T
/
Transducción de Señal
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Diferenciación Celular
/
Linaje de la Célula
/
Factor de Transcripción GATA3
Límite:
Animals
Idioma:
En
Revista:
Blood
Año:
2013
Tipo del documento:
Article
País de afiliación:
Francia