M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding.
Retrovirology
; 10: 12, 2013 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-23375046
ABSTRACT
BACKGROUND:
HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen.FINDINGS:
To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding.CONCLUSIONS:
M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Virión
/
Antígenos CD4
/
Proteína gp120 de Envoltorio del VIH
/
VIH-1
/
Fármacos Anti-VIH
/
Biomimética
Tipo de estudio:
Risk_factors_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Retrovirology
Asunto de la revista:
VIROLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Bélgica