New decision-tree model for defining the risk of reproductive failure.
Am J Reprod Immunol
; 70(1): 59-68, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23480226
ABSTRACT
PROBLEM:
Natural killer (NK) cells play a key role in embryo implantation and pregnancy success, whereas blood and uterine NK expansions have been involved in the pathophysiology of reproductive failure (RF). Our main goal was to design in a large observational study a tree-model decision for interpretation of risk factors for RF. METHODS OF STUDY A hierarchical multivariate decision model based on a classification and regression tree was developed. NK and NKT-like cell subsets were analyzed by flow cytometry.RESULTS:
By multivariate analysis, blood NK cells expansion was an independent risk factor for RF (both recurrent miscarriages and implantation failures). We propose a new decision-tree model for the risk interpretation of women with RF based on a combination of main risk factors.CONCLUSIONS:
Women with age above 35 years and >13% CD56âºCD16⺠NK cells showed the highest risk of further pregnancy loss (100%).
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células Asesinas Naturales
/
Aborto Habitual
/
Técnicas de Apoyo para la Decisión
/
Receptores de IgG
/
Antígeno CD56
/
Pérdida del Embrión
Tipo de estudio:
Etiology_studies
/
Health_economic_evaluation
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Am J Reprod Immunol
Año:
2013
Tipo del documento:
Article
País de afiliación:
España