Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans.

Maurya, Indresh Kumar; Thota, Chaitanya Kumar; Verma, Sachin Dev; Sharma, Jyotsna; Rawal, Manpreet Kaur; Ravikumar, Balaguru; Sen, Sobhan; Chauhan, Neeraj; Lynn, Andrew M; Chauhan, Virander Singh; Prasad, Rajendra

Maurya, Indresh Kumar; Thota, Chaitanya Kumar; Verma, Sachin Dev; Sharma, Jyotsna; Rawal, Manpreet Kaur; Ravikumar, Balaguru; Sen, Sobhan; Chauhan, Neeraj; Lynn, Andrew M; Chauhan, Virander Singh; Prasad, Rajendra.

Afiliación

Maurya IK; Membrane Biology Laboratory, School of Life Sciences, New Delhi 110067, India.
Thota CK; International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India.
Verma SD; School of Physical Sciences, New Delhi 110067, India.
Sharma J; International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India.
Rawal MK; Membrane Biology Laboratory, School of Life Sciences, New Delhi 110067, India.
Ravikumar B; School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Sen S; School of Physical Sciences, New Delhi 110067, India.
Chauhan N; Public Health Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103.
Lynn AM; School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Chauhan VS; International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India. Electronic address: virander@icgeb.res.in.
Prasad R; Membrane Biology Laboratory, School of Life Sciences, New Delhi 110067, India. Electronic address: rp47@mail.jnu.ac.in.

J Biol Chem ; 288(23): 16775-16787, 2013 Jun 07.

Article en En | MEDLINE | ID: mdl-23592791

Asunto(s)

Antifúngicos/farmacología; Azoles; Materiales Biomiméticos/farmacología; Candida albicans/metabolismo; Farmacorresistencia Fúngica/efectos de los fármacos; Proteínas Fúngicas/antagonistas & inhibidores; Péptidos/farmacología; Antifúngicos/química; Materiales Biomiméticos/química; Candida albicans/genética; Proteínas Fúngicas/genética; Proteínas Fúngicas/metabolismo; Humanos; Proteínas de Transporte de Membrana/genética; Proteínas de Transporte de Membrana/metabolismo; Péptidos/química; Estructura Secundaria de Proteína

Palabras clave

ABC Transporter; Antagonist; Candida albicans; Cdr1 Protein; Drug Design; Efflux Pump; Membrane Proteins; Multidrug Transporters; Time Correlation Single Photon Counting (TCSPC); Transmembrane Peptide Mimics

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos / Azoles / Candida albicans / Proteínas Fúngicas / Farmacorresistencia Fúngica / Materiales Biomiméticos / Antifúngicos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2013 Tipo del documento: Article País de afiliación: India

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