Macromolecular juggling by ubiquitylation enzymes.
BMC Biol
; 11: 65, 2013 Jun 25.
Article
en En
| MEDLINE
| ID: mdl-23800009
ABSTRACT
The posttranslational modification of target proteins with ubiquitin and ubiquitin-like proteins is accomplished by the sequential action of E1, E2, and E3 enzymes. Members of the E1 and E3 enzyme families can undergo particularly large conformational changes during their catalytic cycles, involving the remodeling of domain interfaces. This enables the efficient, directed and regulated handover of ubiquitin from one carrier to the next one. We review some of these conformational transformations, as revealed by crystallographic studies.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complejos de Ubiquitina-Proteína Ligasa
/
Sustancias Macromoleculares
/
Ubiquitinación
Límite:
Animals
/
Humans
Idioma:
En
Revista:
BMC Biol
Asunto de la revista:
BIOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos