Autonomic functioning in irritable bowel syndrome measured by heart rate variability: a meta-analysis.
J Dig Dis
; 14(12): 638-46, 2013 Dec.
Article
en En
| MEDLINE
| ID: mdl-23927739
ABSTRACT
OBJECTIVE:
To analyze autonomic functioning which presented as the high frequency (HF) component of heart rate variability, a measurement of vagal tone, and the ratio of low frequency (LF) to HF (LF HF), an indicator of sympathovagal balance in irritable bowel syndrome (IBS) patients.METHODS:
We identified relevant studies by performing a literature search of MEDLINE, EMBASE and the ISI Web of Knowledge to 31 March 2013. Pooled effect sizes with 95% confidence interval (CI) were calculated using a random effects model. Between-study heterogeneity was assessed using the Q test and I(2) statistic.RESULTS:
In all, 11 articles including 392 IBS patients and 263 controls met the inclusion criteria of the analysis. IBS patients had lower HF band power (Hedges's g = -0.38, 95% CI -0.68 to -0.09) than the controls (I(2) = 63.6%, P = 0.003). Moreover, IBS patients showed a higher LF HF (Hedges's g = 0.43, 95% CI 0.13-0.74), with no significant heterogeneity. A subgroup analysis of the HF index according to the recording time yielded different results for the IBS patients and controls. Additionally, constipation-predominant IBS (IBS-C) patients had decreased HF band power, whereas no significant difference was found in LF HF.CONCLUSIONS:
Impaired parasympathetic functioning and abnormal sympathovagal balance may be involved in the pathogenesis of IBS. Vagal dysfunction is more obvious in the IBS-C subgroup.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades del Sistema Nervioso Autónomo
/
Síndrome del Colon Irritable
/
Frecuencia Cardíaca
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
J Dig Dis
Año:
2013
Tipo del documento:
Article
País de afiliación:
China