Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family.
Science
; 247(4940): 324-7, 1990 Jan 19.
Article
en En
| MEDLINE
| ID: mdl-2404337
ABSTRACT
Interleukin-3 (IL-3) binds to its receptor with high and low affinities, induces tyrosine phosphorylation, and promotes the proliferation and differentiation of hematopoietic cells. A binding component of the IL-3 receptor was cloned. Fibroblasts transfected with the complementary DNA bound IL-3 with a low affinity [dissociation constant (Kd) of 17.9 +/- 3.6 nM]. No consensus sequence for a tyrosine kinase was present in the cytoplasmic domain. Thus, additional components are required for a functional high affinity IL-3 receptor. A sequence comparison of the IL-3 receptor with other cytokine receptors (erythropoietin, IL-4, IL-6, and the beta chain IL-2 receptor) revealed a common motif of a distinct receptor gene family.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores Inmunológicos
/
Clonación Molecular
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1990
Tipo del documento:
Article