Long-term incubation with proteasome inhibitors (PIs) induces I&#954;B&#945; degradation via the lysosomal pathway in an I&#954;B kinase (IKK)-dependent and IKK-independent manner.

Lee, Kyoung-Hee; Jeong, Jiyeong; Yoo, Chul-Gyu

Long-term incubation with proteasome inhibitors (PIs) induces IκBα degradation via the lysosomal pathway in an IκB kinase (IKK)-dependent and IKK-independent manner.

Lee, Kyoung-Hee; Jeong, Jiyeong; Yoo, Chul-Gyu.

Afiliación

Lee KH; From the Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine; the Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Korea; the Lung Institute, Medical Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea.
Jeong J; From the Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine; the Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Korea; the Lung Institute, Medical Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea.
Yoo CG; From the Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine; the Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Korea; the Lung Institute, Medical Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea. Electronic address: cgyoo@snu.ac.kr.

J Biol Chem ; 288(45): 32777-32786, 2013 Nov 08.

Article en En | MEDLINE | ID: mdl-24085292

Asunto(s)

Quinasa I-kappa B/metabolismo; Proteínas I-kappa B/metabolismo; Lisosomas/metabolismo; FN-kappa B/metabolismo; Inhibidores de Proteasoma/farmacología; Proteolisis/efectos de los fármacos; Antineoplásicos/farmacología; Ácidos Borónicos/farmacología; Bortezomib; Línea Celular Tumoral; Dipéptidos/farmacología; Regulación de la Expresión Génica/efectos de los fármacos; Regulación de la Expresión Génica/genética; Glucógeno Sintasa Quinasa 3/genética; Glucógeno Sintasa Quinasa 3/metabolismo; Glucógeno Sintasa Quinasa 3 beta; Humanos; Quinasa I-kappa B/genética; Proteínas I-kappa B/genética; Interleucina-8/biosíntesis; Interleucina-8/genética; Cetonas/farmacología; Leupeptinas/farmacología; Lisosomas/genética; Proteínas Asociadas a Microtúbulos/genética; Proteínas Asociadas a Microtúbulos/metabolismo; Mutación Missense; Inhibidor NF-kappaB alfa; Pirazinas/farmacología; Tiofenos/farmacología; Factores de Tiempo

Palabras clave

Anticancer Drug; GSK-3ß; IKK; IκB; Lung Cancer; Lysosome; Lysosomes; Proteasome; Proteasome Inhibitor; Signal Transduction

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: FN-kappa B / Proteínas I-kappa B / Quinasa I-kappa B / Proteolisis / Inhibidores de Proteasoma / Lisosomas Límite: Humans Idioma: En Revista: J Biol Chem Año: 2013 Tipo del documento: Article

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