Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells.

Morita, Akinori; Tanimoto, Keiji; Murakami, Tomoki; Morinaga, Takeshi; Hosoi, Yoshio

Morita, Akinori; Tanimoto, Keiji; Murakami, Tomoki; Morinaga, Takeshi; Hosoi, Yoshio.

Afiliación

Morita A; Department of Radiation Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan; Department of Radiological Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8509, Japan. Electronic address: m
Tanimoto K; Department of Radiation Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan.
Murakami T; Department of Radiation Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan.
Morinaga T; Department of Radiation Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan.
Hosoi Y; Department of Radiation Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan; Department of Radiation Biology, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan. Electronic address: hosoi@med.tohoku.ac.jp.

Biochem Biophys Res Commun ; 443(4): 1286-90, 2014 Jan 24.

Article en En | MEDLINE | ID: mdl-24406161

Asunto(s)

Proteínas de la Ataxia Telangiectasia Mutada/metabolismo; Hepatoblastoma/metabolismo; Neoplasias Hepáticas/metabolismo; Mitocondrias Hepáticas/metabolismo; Daño del ADN; ADN Mitocondrial/genética; ADN Mitocondrial/metabolismo; ADN de Neoplasias/genética; ADN de Neoplasias/metabolismo; Activación Enzimática/efectos de los fármacos; Células Hep G2; Hepatoblastoma/genética; Humanos; Peróxido de Hidrógeno/farmacología; Neoplasias Hepáticas/genética; Estrés Oxidativo; Peroxisomas/metabolismo

Palabras clave

ATM; Hydrogen peroxide; Mitochondria; Oxidative stress; Peroxisome

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Mitocondrias Hepáticas / Hepatoblastoma / Proteínas de la Ataxia Telangiectasia Mutada / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2014 Tipo del documento: Article

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