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Meta-analysis of loci associated with age at natural menopause in African-American women.
Chen, Christina T L; Liu, Ching-Ti; Chen, Gary K; Andrews, Jeanette S; Arnold, Alice M; Dreyfus, Jill; Franceschini, Nora; Garcia, Melissa E; Kerr, Kathleen F; Li, Guo; Lohman, Kurt K; Musani, Solomon K; Nalls, Michael A; Raffel, Leslie J; Smith, Jennifer; Ambrosone, Christine B; Bandera, Elisa V; Bernstein, Leslie; Britton, Angela; Brzyski, Robert G; Cappola, Anne; Carlson, Christopher S; Couper, David; Deming, Sandra L; Goodarzi, Mark O; Heiss, Gerardo; John, Esther M; Lu, Xiaoning; Le Marchand, Loic; Marciante, Kristin; Mcknight, Barbara; Millikan, Robert; Nock, Nora L; Olshan, Andrew F; Press, Michael F; Vaiyda, Dhananjay; Woods, Nancy F; Taylor, Herman A; Zhao, Wei; Zheng, Wei; Evans, Michele K; Harris, Tamara B; Henderson, Brian E; Kardia, Sharon L R; Kooperberg, Charles; Liu, Yongmei; Mosley, Thomas H; Psaty, Bruce; Wellons, Melissa; Windham, Beverly G.
Afiliación
  • Chen CT; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA ctchen@fhcrc.org rajkovic@upmc.edu murabito@bu.edu christopher.haiman@med.usc.edu.
  • Liu CT; Department of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
  • Chen GK; Department of Preventive Medicine.
  • Andrews JS; Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
  • Arnold AM; Department of Biostatistics.
  • Dreyfus J; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.
  • Franceschini N; Department of Epidemiology, Gillings School of Global Public Health.
  • Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD 20814, USA.
  • Kerr KF; Department of Biostatistics.
  • Li G; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
  • Lohman KK; Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
  • Musani SK; University of Mississippi Medical Center, Jackson, MS 39216, USA.
  • Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
  • Raffel LJ; Department of Pediatrics and Biomedical Sciences.
  • Smith J; Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Ambrosone CB; Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
  • Bandera EV; The Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.
  • Bernstein L; Division of Cancer Etiology, Department of Population Science, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.
  • Britton A; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
  • Brzyski RG; Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
  • Cappola A; Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Carlson CS; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Couper D; Department of Biostatistics, Gillings School of Global Public Health.
  • Deming SL; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Goodarzi MO; Division of Endocrinology, Diabetes, and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Heiss G; Department of Epidemiology, Gillings School of Global Public Health.
  • John EM; Division of Epidemiology, Department of Health Research & Policy, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Lu X; Department of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA Division of Clinical Informatics, Beth Israel Deaconess Medical Center, Boston, MA 02118, USA.
  • Le Marchand L; Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA.
  • Marciante K; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
  • Mcknight B; Department of Biostatistics.
  • Millikan R; Department of Epidemiology, Gillings School of Global Public Health Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA.
  • Nock NL; Department of Epidemiology and Biostatistics, Case Western University, Cleveland, OH 44106, USA.
  • Olshan AF; Department of Epidemiology, Gillings School of Global Public Health Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA.
  • Press MF; Department of Pathology, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.
  • Vaiyda D; Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
  • Woods NF; Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA 98109, USA.
  • Taylor HA; University of Mississippi Medical Center, Jackson, MS 39216, USA.
  • Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Evans MK; Health Disparities Research Section, Clinical Research Branch.
  • Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD 20814, USA.
  • Henderson BE; Department of Preventive Medicine.
  • Kardia SL; Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Liu Y; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
  • Mosley TH; Division of Geriatric Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
  • Psaty B; Departments of Medicine, Epidemiology and Health Services, University of Washington and Group Health Research Institute, Seattle, WA, USA.
  • Wellons M; School of Medicine, Vanderbilt University, Nashville, TN 37240, USA.
  • Windham BG; Division of Geriatric Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Hum Mol Genet ; 23(12): 3327-42, 2014 Jun 15.
Article en En | MEDLINE | ID: mdl-24493794
ABSTRACT
Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05) AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Negro o Afroamericano / Menopausia / Población Blanca Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans País/Región como asunto: America do norte Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Negro o Afroamericano / Menopausia / Población Blanca Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans País/Región como asunto: America do norte Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2014 Tipo del documento: Article