Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases.

Kober, Daniel L; Wanhainen, Kelsey M; Johnson, Britney M; Randolph, David T; Holtzman, Michael J; Brett, Tom J

Kober, Daniel L; Wanhainen, Kelsey M; Johnson, Britney M; Randolph, David T; Holtzman, Michael J; Brett, Tom J.

Afiliación

Kober DL; Molecular Microbiology and Microbial Pathogenesis Program, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, United States.
Wanhainen KM; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, United States.
Johnson BM; Biochemistry Program, Washington University School of Medicine, St. Louis, MO 63110, United States.
Randolph DT; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, United States.
Holtzman MJ; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, United States; Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, United States; Drug Discovery Program in Pulmonary and Critical Care Medicine, Washington Univers
Brett TJ; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, United States; Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, United States; Cell Biology and Physiology, Washington University School of Medicine, S

Protein Expr Purif ; 96: 32-8, 2014 Apr.

Article en En | MEDLINE | ID: mdl-24508568

Asunto(s)

Inflamación/patología; Glicoproteínas de Membrana/genética; Glicoproteínas de Membrana/ultraestructura; Enfermedades Neurodegenerativas/patología; Receptores Inmunológicos/genética; Receptores Inmunológicos/ultraestructura; Clonación Molecular; Cristalografía por Rayos X; Expresión Génica; Humanos; Glicoproteínas de Membrana/biosíntesis; Mutación; Pliegue de Proteína; Estructura Terciaria de Proteína; Receptores Inmunológicos/biosíntesis

Palabras clave

Alzheimer's disease; Crystallography; Inflammation; Innate immunity; Neurodegenerative disease; Parkinson's disease; Receptor

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Glicoproteínas de Membrana / Receptores Inmunológicos / Enfermedades Neurodegenerativas / Inflamación Límite: Humans Idioma: En Revista: Protein Expr Purif Asunto de la revista: BIOLOGIA MOLECULAR Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos

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