Effect of vitamin D on postoperative adhesion formation in a rat uterine horn adhesion model.
J Reprod Med
; 58(11-12): 511-6, 2013.
Article
en En
| MEDLINE
| ID: mdl-24568046
ABSTRACT
OBJECTIVE:
To determine the role of vitamin D for preventing or reducing postoperative adhesions. STUDYDESIGN:
The uterine horn adhesion model was carried out in 24 female Wistar rats. The animals were randomized into 4 groups (1) control, (2) Ringer's lactate, (3) olive oil, and (4) vitamin D. Adhesion grade and histologic findings of adhesion-carrying tissues were evaluated, and groups were compared according to these parameters.RESULTS:
Rats treated with vitamin D had less adhesion and lower inflammation grade when compared to the control and Ringer's lactate groups, and the results were statistically significant (p < 0.05). On the other hand, no difference was detected between the groups according to the fibrosis score.CONCLUSION:
Vitamin D decreased postsurgical adhesion scores by both visual scores and histologic analyses in a rat model. Further experimental and clinical trials are required to confirm these results.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Uterinas
/
Vitamina D
/
Adherencias Tisulares
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Reprod Med
Año:
2013
Tipo del documento:
Article
País de afiliación:
Turquía