Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream.
J Am Acad Dermatol
; 70(5): 918-23, 2014 May.
Article
en En
| MEDLINE
| ID: mdl-24655819
ABSTRACT
BACKGROUND:
Traditional pharmacotherapy for onychomycosis has low to moderate efficacy and may be associated with adverse reactions and medication interactions limiting its use in many patients.OBJECTIVE:
We evaluated the clinical efficacy and safety of a fractional carbon-dioxide laser with topical antifungal therapy in the treatment of onychomycosis.METHODS:
In all, 24 patients were treated with fractional carbon-dioxide laser therapy and a topical antifungal cream. The laser treatment consisted of 3 sessions at 4-week intervals. Efficacy was assessed based on the response rate from standardized photographs, a microscopic examination of subungual debris, and subjective evaluations.RESULTS:
Among the patients, 92% showed a clinical response and 50% showed a complete response with a negative microscopic result. The factors that influenced a successful outcome were the type of onychomycosis and the thickness of the nail plate before treatment. The treatment regimen was well tolerated and there was no recurrence 3 months after the last treatment episode.LIMITATIONS:
The study followed up only 24 patients and there were no relevant treatment controls.CONCLUSIONS:
Fractional carbon-dioxide laser therapy, combined with a topical antifungal agent, was effective in the treatment of onychomycosis. It should be considered an alternative therapeutic option in patients for whom systemic antifungal agents are contraindicated.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Morfolinas
/
Onicomicosis
/
Láseres de Gas
/
Antifúngicos
Límite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Am Acad Dermatol
Año:
2014
Tipo del documento:
Article