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Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.
Phuan, Puay-Wah; Veit, Guido; Tan, Joseph; Roldan, Ariel; Finkbeiner, Walter E; Lukacs, Gergely L; Verkman, A S.
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  • Phuan PW; Departments of Medicine and Physiology (P.-W.P., J.T., A.S.V.) and Department of Pathology (W.E.F.), University of California, San Francisco, California; and Groupe de Recherche Axé sur la Structure des Protéine and Departments of Physiology (G.V., A.R., G.L.L.) and Biochemistry (G.L.L.), McGill Uni
  • Veit G; Departments of Medicine and Physiology (P.-W.P., J.T., A.S.V.) and Department of Pathology (W.E.F.), University of California, San Francisco, California; and Groupe de Recherche Axé sur la Structure des Protéine and Departments of Physiology (G.V., A.R., G.L.L.) and Biochemistry (G.L.L.), McGill Uni
  • Tan J; Departments of Medicine and Physiology (P.-W.P., J.T., A.S.V.) and Department of Pathology (W.E.F.), University of California, San Francisco, California; and Groupe de Recherche Axé sur la Structure des Protéine and Departments of Physiology (G.V., A.R., G.L.L.) and Biochemistry (G.L.L.), McGill Uni
  • Roldan A; Departments of Medicine and Physiology (P.-W.P., J.T., A.S.V.) and Department of Pathology (W.E.F.), University of California, San Francisco, California; and Groupe de Recherche Axé sur la Structure des Protéine and Departments of Physiology (G.V., A.R., G.L.L.) and Biochemistry (G.L.L.), McGill Uni
  • Finkbeiner WE; Departments of Medicine and Physiology (P.-W.P., J.T., A.S.V.) and Department of Pathology (W.E.F.), University of California, San Francisco, California; and Groupe de Recherche Axé sur la Structure des Protéine and Departments of Physiology (G.V., A.R., G.L.L.) and Biochemistry (G.L.L.), McGill Uni
  • Lukacs GL; Departments of Medicine and Physiology (P.-W.P., J.T., A.S.V.) and Department of Pathology (W.E.F.), University of California, San Francisco, California; and Groupe de Recherche Axé sur la Structure des Protéine and Departments of Physiology (G.V., A.R., G.L.L.) and Biochemistry (G.L.L.), McGill Uni
  • Verkman AS; Departments of Medicine and Physiology (P.-W.P., J.T., A.S.V.) and Department of Pathology (W.E.F.), University of California, San Francisco, California; and Groupe de Recherche Axé sur la Structure des Protéine and Departments of Physiology (G.V., A.R., G.L.L.) and Biochemistry (G.L.L.), McGill Uni
Mol Pharmacol ; 86(1): 42-51, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24737137
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulador de Conductancia de Transmembrana de Fibrosis Quística / Mucosa Respiratoria / Benzodioxoles / Bibliotecas de Moléculas Pequeñas / Aminopiridinas Límite: Animals / Humans Idioma: En Revista: Mol Pharmacol Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulador de Conductancia de Transmembrana de Fibrosis Quística / Mucosa Respiratoria / Benzodioxoles / Bibliotecas de Moléculas Pequeñas / Aminopiridinas Límite: Animals / Humans Idioma: En Revista: Mol Pharmacol Año: 2014 Tipo del documento: Article