The long elusive IgM Fc receptor, FcµR.
J Clin Immunol
; 34 Suppl 1: S35-45, 2014 Jul.
Article
en En
| MEDLINE
| ID: mdl-24793544
ABSTRACT
IgM exists as both a monomer on the surface of B cells and a pentamer secreted by plasma cells. Both pre-immune "natural" and antigen-induced "immune" IgM antibodies are important for protective immunity and for immune regulation of autoimmune processes by recognizing pathogens and self-antigens. Effector proteins interacting with the Fc portion of IgM, such as complement and complement receptors, have thus far been proposed but fail to fully account for the IgM-mediated protection and regulation. A major reason for this deficit in our understanding of IgM function seems to be lack of data on a long elusive Fc receptor for IgM (FcµR). We have recently identified a bona fide FcµR in both humans and mice. In this article we briefly review what we have learned so far about FcµR.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Inmunoglobulina M
/
Linfocitos B
/
Receptores Fc
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Clin Immunol
Año:
2014
Tipo del documento:
Article