4-Benzothiazole-7-hydroxyindolinyl diaryl ureas are potent P2Y1 antagonists with favorable pharmacokinetics: low clearance and small volume of distribution.

Qiao, Jennifer X; Wang, Tammy C; Hiebert, Sheldon; Hu, Carol H; Schumacher, William A; Spronk, Steven A; Clark, Charles G; Han, Ying; Hua, Ji; Price, Laura A; Shen, Hong; Chacko, Silvi A; Everlof, Gerry; Bostwick, Jeffrey S; Steinbacher, Thomas E; Li, Yi-Xin; Huang, Christine S; Seiffert, Dietmar A; Rehfuss, Robert; Wexler, Ruth R; Lam, Patrick Y S

Qiao, Jennifer X; Wang, Tammy C; Hiebert, Sheldon; Hu, Carol H; Schumacher, William A; Spronk, Steven A; Clark, Charles G; Han, Ying; Hua, Ji; Price, Laura A; Shen, Hong; Chacko, Silvi A; Everlof, Gerry; Bostwick, Jeffrey S; Steinbacher, Thomas E; Li, Yi-Xin; Huang, Christine S; Seiffert, Dietmar A; Rehfuss, Robert; Wexler, Ruth R; Lam, Patrick Y S.

Afiliación

Qiao JX; Medicinal Chemistry, Molecular Sciences and Candidate Optimization, Bristol-Myers Squibb Company, Rt. 206 and Province Line Road, Princeton, NJ 08543 (USA). Jennifer.qiao@bms.com.

ChemMedChem ; 9(10): 2327-43, 2014 Oct.

Article en En | MEDLINE | ID: mdl-24989964

Asunto(s)

Antagonistas del Receptor Purinérgico P2Y/farmacología; Urea/análogos & derivados; Animales; Humanos; Espectroscopía de Resonancia Magnética; Antagonistas del Receptor Purinérgico P2Y/farmacocinética; Espectrometría de Masa por Ionización de Electrospray; Urea/farmacocinética; Urea/farmacología

Palabras clave

P2Y1 antagonist; anionically active trifluoromethyl groups; antiplatelet; clearance; structure-activity relationships; volume of distribution

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Urea / Antagonistas del Receptor Purinérgico P2Y Límite: Animals / Humans Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2014 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google