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Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).
Jayatunga, Madura K P; Thompson, Sam; McKee, Tawnya C; Chan, Mun Chiang; Reece, Kelie M; Hardy, Adam P; Sekirnik, Rok; Seden, Peter T; Cook, Kristina M; McMahon, James B; Figg, William D; Schofield, Christopher J; Hamilton, Andrew D.
Afiliación
  • Jayatunga MK; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom.
  • Thompson S; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom. Electronic address: sam.thompson@chem.ox.ac.uk.
  • McKee TC; Center for Cancer Research, Molecular Targets Laboratory, Frederick National Laboratory Cancer Research, Frederick, MD 21702, USA.
  • Chan MC; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom.
  • Reece KM; NCI, Mol. Pharmacol. Sect., Med. Oncol. Branch, Ctr. Canc. Res., NIH, Bldg. 10, Room 5A01, 9000 Rockville Pike, Bethesda, MD 20892, USA.
  • Hardy AP; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom.
  • Sekirnik R; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom.
  • Seden PT; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom.
  • Cook KM; NCI, Mol. Pharmacol. Sect., Med. Oncol. Branch, Ctr. Canc. Res., NIH, Bldg. 10, Room 5A01, 9000 Rockville Pike, Bethesda, MD 20892, USA.
  • McMahon JB; Center for Cancer Research, Molecular Targets Laboratory, Frederick National Laboratory Cancer Research, Frederick, MD 21702, USA.
  • Figg WD; NCI, Mol. Pharmacol. Sect., Med. Oncol. Branch, Ctr. Canc. Res., NIH, Bldg. 10, Room 5A01, 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address: figgw@helix.nih.gov.
  • Schofield CJ; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom.
  • Hamilton AD; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom. Electronic address: andrew.hamilton@admin.ox.ac.uk.
Eur J Med Chem ; 94: 509-16, 2015 Apr 13.
Article en En | MEDLINE | ID: mdl-25023609
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Quinonas / Zinc / Proteína p300 Asociada a E1A / Subunidad alfa del Factor 1 Inducible por Hipoxia / Indanos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Quinonas / Zinc / Proteína p300 Asociada a E1A / Subunidad alfa del Factor 1 Inducible por Hipoxia / Indanos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido