c-Myc programs fatty acid metabolism and dictates acetyl-CoA abundance and fate.

Edmunds, Lia R; Sharma, Lokendra; Kang, Audry; Lu, Jie; Vockley, Jerry; Basu, Shrabani; Uppala, Radha; Goetzman, Eric S; Beck, Megan E; Scott, Donald; Prochownik, Edward V

Edmunds, Lia R; Sharma, Lokendra; Kang, Audry; Lu, Jie; Vockley, Jerry; Basu, Shrabani; Uppala, Radha; Goetzman, Eric S; Beck, Megan E; Scott, Donald; Prochownik, Edward V.

Afiliación

Edmunds LR; From the Divisions of Hematology/Oncology and.
Sharma L; From the Divisions of Hematology/Oncology and.
Kang A; From the Divisions of Hematology/Oncology and.
Lu J; From the Divisions of Hematology/Oncology and.
Vockley J; Medical Genetics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania 15224.
Basu S; Medical Genetics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania 15224.
Uppala R; Medical Genetics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania 15224.
Goetzman ES; Medical Genetics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania 15224.
Beck ME; Medical Genetics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania 15224.
Scott D; the Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine, Mt. Sinai School of Medicine, New York, New York 10029.
Prochownik EV; From the Divisions of Hematology/Oncology and the Department of Microbiology and Molecular Genetics, The University of Pittsburgh, Pittsburgh, Pennsylvania 15219, and the University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15224 procev@chp.edu.

J Biol Chem ; 289(36): 25382-92, 2014 Sep 05.

Article en En | MEDLINE | ID: mdl-25053415

Asunto(s)

Acetilcoenzima A/metabolismo; Ácidos Grasos/metabolismo; Fibroblastos/metabolismo; Proteínas Proto-Oncogénicas c-myc/metabolismo; Proteínas Quinasas Activadas por AMP/genética; Proteínas Quinasas Activadas por AMP/metabolismo; Adenosina Trifosfato/metabolismo; Animales; Western Blotting; Línea Celular Tumoral; Ciclo del Ácido Cítrico; Fibroblastos/citología; Perfilación de la Expresión Génica; Técnicas de Inactivación de Genes; Glucólisis; Humanos; Cetona Oxidorreductasas/genética; Cetona Oxidorreductasas/metabolismo; Metabolismo de los Lípidos; Redes y Vías Metabólicas/genética; Oxidación-Reducción; Fosforilación Oxidativa; Proteínas Proto-Oncogénicas c-myc/genética; Ácido Pirúvico/metabolismo; Interferencia de ARN; Ratas; Reacción en Cadena de la Polimerasa de Transcriptasa Inversa

Palabras clave

AMP-activated Kinase (AMPK); Electron Transfer Complex; Mitochondria; Pyruvate Dehydrogenase Complex (PDC); Tricarboxylic Acid Cycle (TCA Cycle) (Krebs cycle); Warburg Effect

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Acetilcoenzima A / Proteínas Proto-Oncogénicas c-myc / Ácidos Grasos / Fibroblastos Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article

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