Hyperreactivity of junctional adhesion molecule A-deficient platelets accelerates atherosclerosis in hyperlipidemic mice.

Karshovska, Ela; Zhao, Zhen; Blanchet, Xavier; Schmitt, Martin M N; Bidzhekov, Kiril; Soehnlein, Oliver; von Hundelshausen, Philipp; Mattheij, Nadine J; Cosemans, Judith M E M; Megens, Remco T A; Koeppel, Thomas A; Schober, Andreas; Hackeng, Tilman M; Weber, Christian; Koenen, Rory R

Karshovska, Ela; Zhao, Zhen; Blanchet, Xavier; Schmitt, Martin M N; Bidzhekov, Kiril; Soehnlein, Oliver; von Hundelshausen, Philipp; Mattheij, Nadine J; Cosemans, Judith M E M; Megens, Remco T A; Koeppel, Thomas A; Schober, Andreas; Hackeng, Tilman M; Weber, Christian; Koenen, Rory R.

Afiliación

Karshovska E; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
Zhao Z; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
Blanchet X; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
Schmitt MM; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
Bidzhekov K; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
Soehnlein O; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
von Hundelshausen P; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
Mattheij NJ; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
Cosemans JM; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
Megens RT; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
Koeppel TA; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
Schober A; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
Hackeng TM; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
Weber C; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce
Koenen RR; From the Institute for Cardiovascular Prevention (IPEK) (E.K., Z.Z., X.B., M.M.N.S., K.B., O.S., P.v.H., R.T.A.M., A.S., C.W., R.R.K.) and Division of Vascular and Endovascular Surgery (Z.Z., T.A.K.), Ludwig-Maximilians-University Munich, Munich, Germany; Department of Pathology, Academic Medical Ce

Circ Res ; 116(4): 587-99, 2015 Feb 13.

Article en En | MEDLINE | ID: mdl-25472975

Asunto(s)

Aorta/metabolismo; Enfermedades de la Aorta/etiología; Aterosclerosis/etiología; Plaquetas/metabolismo; Enfermedades de las Arterias Carótidas/etiología; Moléculas de Adhesión Celular/deficiencia; Hiperlipidemias/complicaciones; Agregación Plaquetaria; Receptores de Superficie Celular/deficiencia; Animales; Aorta/patología; Enfermedades de la Aorta/sangre; Enfermedades de la Aorta/genética; Enfermedades de la Aorta/patología; Apolipoproteínas E/deficiencia; Apolipoproteínas E/genética; Aterosclerosis/sangre; Aterosclerosis/genética; Aterosclerosis/patología; Enfermedades de las Arterias Carótidas/sangre; Enfermedades de las Arterias Carótidas/genética; Enfermedades de las Arterias Carótidas/patología; Adhesión Celular; Moléculas de Adhesión Celular/sangre; Moléculas de Adhesión Celular/genética; Células Cultivadas; Quimiotaxis de Leucocito; Dieta Alta en Grasa; Modelos Animales de Enfermedad; Progresión de la Enfermedad; Femenino; Genotipo; Humanos; Hiperlipidemias/sangre; Hiperlipidemias/genética; Mediadores de Inflamación/metabolismo; Leucocitos/metabolismo; Masculino; Ratones Endogámicos C57BL; Ratones Noqueados; Fenotipo; Placa Aterosclerótica; Complejo GPIIb-IIIa de Glicoproteína Plaquetaria/metabolismo; Proteína Tirosina Fosfatasa no Receptora Tipo 1/metabolismo; Receptores de Superficie Celular/sangre; Receptores de Superficie Celular/genética; Trombosis/sangre; Trombosis/etiología; Factores de Tiempo; Familia-src Quinasas/metabolismo

Palabras clave

atherosclerosis; blood platelets; cell adhesion molecules; inflammation; phosphoprotein phosphatases

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aorta / Enfermedades de la Aorta / Plaquetas / Enfermedades de las Arterias Carótidas / Moléculas de Adhesión Celular / Agregación Plaquetaria / Receptores de Superficie Celular / Aterosclerosis / Hiperlipidemias Tipo de estudio: Etiology_studies / Prognostic_studies Idioma: En Revista: Circ Res Año: 2015 Tipo del documento: Article

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