Heart dose reduction by prone deep inspiration breath hold in left-sided breast irradiation.
Radiother Oncol
; 114(1): 79-84, 2015 Jan.
Article
en En
| MEDLINE
| ID: mdl-25497557
ABSTRACT
BACKGROUND AND PURPOSE:
Cardiac disease has been related to heart dose after left-sided breast radiotherapy. This trial evaluates the heart sparing ability and feasibility of deep inspiration breath hold (DIBH) in the prone position for left-sided whole breast irradiation (WBI). MATERIALS ANDMETHODS:
Twelve patients underwent CT-simulation in supine shallow breathing (SB), supine DIBH, prone SB and prone DIBH. A validation cohort of 38 patients received prone SB and prone DIBH CT-scans; the last 30 patients were accepted for prone DIBH treatment. WBI was planned with a prescription dose of 40.05 Gy.RESULTS:
DIBH was able to reduce (p<0.001) heart dose in both positions, with results for prone DIBH at least as favorable as for supine DIBH. Mean heart dose was lowered from 2.2 Gy for prone SB to 1.3 Gy for prone DIBH (p<0.001), while preserving the lung sparing ability of prone positioning. Moreover prone DIBH nearly consistently reduced mean heart dose to less then 2 Gy, regardless of breast volume. All patients were able to perform the simulation procedure, 28/30 patients were treated with prone DIBH.CONCLUSIONS:
This trial demonstrates the ability and feasibility of prone DIBH to acquire optimal heart and lung sparing for left-sided WBI.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Inhalación
/
Contencion de la Respiración
/
Corazón
Tipo de estudio:
Clinical_trials
/
Evaluation_studies
Límite:
Adult
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Female
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Humans
/
Middle aged
Idioma:
En
Revista:
Radiother Oncol
Año:
2015
Tipo del documento:
Article