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Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif.
Frankowski, Kevin J; Slauson, Stephen R; Lovell, Kimberly M; Phillips, Angela M; Streicher, John M; Zhou, Lei; Whipple, David A; Schoenen, Frank J; Prisinzano, Thomas E; Bohn, Laura M; Aubé, Jeffrey.
Afiliación
  • Frankowski KJ; University of Kansas Specialized Chemistry Center, 2034 Becker Drive, Lawrence, KS 66047-3761, USA.
  • Slauson SR; University of Kansas Specialized Chemistry Center, 2034 Becker Drive, Lawrence, KS 66047-3761, USA.
  • Lovell KM; Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, 130 Scripps Way, #2A2, Jupiter, FL 33458, USA.
  • Phillips AM; Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, 130 Scripps Way, #2A2, Jupiter, FL 33458, USA.
  • Streicher JM; Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, 130 Scripps Way, #2A2, Jupiter, FL 33458, USA.
  • Zhou L; Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, 130 Scripps Way, #2A2, Jupiter, FL 33458, USA.
  • Whipple DA; University of Kansas Specialized Chemistry Center, 2034 Becker Drive, Lawrence, KS 66047-3761, USA.
  • Schoenen FJ; University of Kansas Specialized Chemistry Center, 2034 Becker Drive, Lawrence, KS 66047-3761, USA.
  • Prisinzano TE; University of Kansas Specialized Chemistry Center, 2034 Becker Drive, Lawrence, KS 66047-3761, USA.
  • Bohn LM; Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, 130 Scripps Way, #2A2, Jupiter, FL 33458, USA. Electronic address: lbohn@scripps.edu.
  • Aubé J; University of Kansas Specialized Chemistry Center, 2034 Becker Drive, Lawrence, KS 66047-3761, USA. Electronic address: jaube@ku.edu.
Bioorg Med Chem ; 23(14): 3948-56, 2015 Jul 15.
Article en En | MEDLINE | ID: mdl-25593096
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Relación Estructura-Actividad / Sulfonamidas / Benzamidas / Receptores Opioides kappa Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Relación Estructura-Actividad / Sulfonamidas / Benzamidas / Receptores Opioides kappa Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos